What is the most important information to provide to a client taking sustained-release nitroglycerin who inquires about sildenafil?

The primary concern when a client is taking sustained-release nitroglycerin and is inquiring about sildenafil is the risk of hypotension. Both nitroglycerin and sildenafil can cause vasodilation, which significantly lowers blood pressure. When administered together, the effects can be additive, potentially leading to a dangerously low blood pressure, which could result in severe complications or even be fatal.

It's crucial for clients to understand that the timing of taking these medications does not mitigate the risk; therefore, they should avoid using them concurrently altogether. This information emphasizes the importance of medication safety and the need for awareness of potential drug interactions that can lead to serious health issues. Ensuring that clients are informed about this risk not only helps them manage their medications safely but also encourages them to discuss any medication regimen changes with their healthcare provider.